| Property |
Value |
| Working Groups |
RG Vona |
| Subproject |
A03 |
| Open Access |
Yes |
| Publication Type |
Preprint |
| Peer Reviewed |
No |
| PMID |
40832383 |
| DOI |
10.1101/2025.08.13.25333146 |
| Publication Year |
2025 |
| Title |
The TECTB-C225Y Variant Causing Autosomal Dominant Deafness in a Nicaraguan Family Enhances Sensitivity to Noise-Induced Hearing Loss in Mice |
| Journal |
medRxiv |
| ISSN |
no ISSN (NLM ID:101767986) |
| URL |
https://doi.org/10.1101/2025.08.13.25333146 |
| Journal Abbreviation |
medRxiv |
| Extra |
Final article published in Advanced Science here: doi:10.1002/advs.77543 |
| Authors |
Hale EB, Vona B, Goodyear RJ, Osgood RT, Amr SS, Mojica K, Vera-Monroy R, Callahan K, Gudlewski KL, Quadros R, Ohtsuka M, McGee J, Walsh EJ, Morton CC, Gurumurthy C, Saunders JE, Richardson GP, Indzhykulian AA |
| First Author |
Hale EB |
| Last Author |
Indzhykulian AA |
External Resources
medrxiv....ll.pdfhttps://www.medrxiv.org/content/10.1101/2025.08.13.25333146v1.full.pdf Article fulltext
2/150912https://publications.goettingen-research-online.de/handle/2/150912 GRO.publications identifier
8277171http://www.informatics.jax.org/allele/MGI:8277171 MGI identifier (8277171)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
NM_058222.3https://www.ncbi.nlm.nih.gov/nuccore/NM_058222.3 NCBI nucleotide (NM_058222.3, reused)
0000-0002-2781-0412https://orcid.org/0000-0002-2781-0412 ORCID identifier (Evan B. Hale)
0000-0002-6719-3447https://orcid.org/0000-0002-6719-3447 ORCID identifier (Barbara Christine Vona)
0000-0001-6698-4127https://orcid.org/0000-0001-6698-4127 ORCID identifier (Richard J. Goodyear)
0000-0003-0927-6057https://orcid.org/0000-0003-0927-6057 ORCID identifier (Sami S. Amr)
0000-0002-0347-9614https://orcid.org/0000-0002-0347-9614 ORCID identifier (Richard Thomas Osgood)
0000-0003-2210-5586https://orcid.org/0000-0003-2210-5586 ORCID identifier (Karen Mojica)
0000-0002-9798-9622https://orcid.org/0000-0002-9798-9622 ORCID identifier (Rolen Quadros)
0000-0002-6952-4238https://orcid.org/0000-0002-6952-4238 ORCID identifier (Masato Ohtsuka)
0000-0003-2207-4660https://orcid.org/0000-0003-2207-4660 ORCID identifier (JoAnn McGee)
0000-0003-2198-6756https://orcid.org/0000-0003-2198-6756 ORCID identifier (Cynthia C. Morton)
0000-0002-8022-4033https://orcid.org/0000-0002-8022-4033 ORCID identifier (Channabasavaiah Gurumurthy)
0000-0002-2076-6818https://orcid.org/0000-0002-2076-6818 ORCID identifier (Artur A. Indzhykulian)
55https://rdp.sfb1690.uni-goettingen.de/literature/publications/55 Published Data Registry entry (CRC 1690, final article)
8/17https://rdp.sfb1690.uni-goettingen.de/archive/8/17 Research Data Archive (supplemental material)
01q9r1072https://ror.org/01q9r1072 ROR identifier (01q9r1072, Boys Town National Research Hospital)
04b6nzv94https://ror.org/04b6nzv94 ROR identifier (04b6nzv94, Brigham and Women's Hospital)
00d1dhh09https://ror.org/00d1dhh09 ROR identifier (00d1dhh09, Dartmouth–Hitchcock Medical Center)
02f99v835https://ror.org/02f99v835 ROR identifier (02f99v835, German Primate Center)
04py2rh25https://ror.org/04py2rh25 ROR identifier (04py2rh25, Mass General Brigham)
00ayhx656https://ror.org/00ayhx656 ROR identifier (00ayhx656, University of Sussex)
03vek6s52https://ror.org/03vek6s52 ROR identifier (03vek6s52, Harvard University)
01p7qe739https://ror.org/01p7qe739 ROR identifier (01p7qe739, Tokai University)
00thqtb16https://ror.org/00thqtb16 ROR identifier (00thqtb16, University of Nebraska Medical Center)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
AB_143157https://scicrunch.org/resolver/AB_143157 SciCrunch identifier (RRID:AB_143157)
AB_399431https://scicrunch.org/resolver/AB_399431 SciCrunch identifier (RRID:AB_399431)
AB_1950505https://scicrunch.org/resolver/AB_1950505 SciCrunch identifier (RRID:AB_1950505)
AB_2337432https://scicrunch.org/resolver/AB_2337432 SciCrunch identifier (RRID:AB_2337432)
AB_2619825https://scicrunch.org/resolver/AB_2619825 SciCrunch identifier (RRID:AB_2619825)
AB_2633275https://scicrunch.org/resolver/AB_2633275 SciCrunch identifier (RRID:AB_2633275)
IMSR_JAX:002756https://scicrunch.org/resolver/IMSR_JAX:002756 SciCrunch identifier (RRID:IMSR_JAX:002756, B6.CAST-Cdh23Ahl+/Kjn)
IMSR_JAX:041413https://scicrunch.org/resolver/IMSR_JAX:041413 SciCrunch identifier (RRID:IMSR_JAX:041413, B6.Cg-Cdh23Ahl+ Tectb/GprIndzJ)
SCR_014199https://scicrunch.org/resolver/SCR_014199 SciCrunch identifier (RRID:SCR_014199, Adobe Photoshop)
SCR_012821https://scicrunch.org/resolver/SCR_012821 SciCrunch identifier (RRID:SCR_012821, ANNOVAR)
SCR_017561https://scicrunch.org/resolver/SCR_017561 SciCrunch identifier (RRID:SCR_017561, Data Browser)
SCR_018393https://scicrunch.org/resolver/SCR_018393 SciCrunch identifier (RRID:SCR_018393, Combined Annotation Dependent Depletion)
SCR_001876https://scicrunch.org/resolver/SCR_001876 SciCrunch identifier (RRID:SCR_001876, GATK)
SCR_014964https://scicrunch.org/resolver/SCR_014964 SciCrunch identifier (RRID:SCR_014964, Genome Aggregation Database)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_003070https://scicrunch.org/resolver/SCR_003070 SciCrunch identifier (RRID:SCR_003070, ImageJ)
SCR_018169https://scicrunch.org/resolver/SCR_018169 SciCrunch identifier (RRID:SCR_018169, Leica SP8 LIGHTNING confocal microscope)
SCR_010777https://scicrunch.org/resolver/SCR_010777 SciCrunch identifier (RRID:SCR_010777, MutationTaster)
SCR_013189https://scicrunch.org/resolver/SCR_013189 SciCrunch identifier (RRID:SCR_013189, PolyPhen)
SCR_008394https://scicrunch.org/resolver/SCR_008394 SciCrunch identifier (RRID:SCR_008394, Python)
SCR_012813https://scicrunch.org/resolver/SCR_012813 SciCrunch identifier (RRID:SCR_012813, SIFT)
medrxiv....d=truehttps://www.medrxiv.org/content/medrxiv/early/2025/08/14/2025.08.13.25333146/DC4/embed/media-4.pdf?download=true Supplemental material (figure)
medrxiv....d=truehttps://www.medrxiv.org/content/medrxiv/early/2025/08/14/2025.08.13.25333146/DC1/embed/media-1.pdf?download=true Supplemental material (table)
medrxiv....d=truehttps://www.medrxiv.org/content/medrxiv/early/2025/08/14/2025.08.13.25333146/DC2/embed/media-2.pdf?download=true Supplemental material (table)
medrxiv....d=truehttps://www.medrxiv.org/content/medrxiv/early/2025/08/14/2025.08.13.25333146/DC3/embed/media-3.pdf?download=true Supplemental material (table)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0004 |
 |
primary |
CtBP2 |
AB_399431 |
Purified Mouse Anti-CtBP2 |
| primary-0073 |
|
primary |
SLC17A8 |
AB_2619825 |
Anti-VGLUT 3 antibody |
| primary-0075 |
|
primary |
Homer1 |
AB_1950505 |
Homer1 antibody |
| secondary-0072 |
|
secondary |
|
AB_143157 |
Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 568 |
| secondary-0074 |
|
secondary |
|
AB_2633275 |
Goat anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ Plus 488 |
| secondary-0076 |
|
secondary |
|
AB_2337432 |
DyLight™ 405 AffiniPure® Goat Anti-Guinea Pig IgG (H+L) |
Linked Mouselines