| Property |
Value |
| Working Groups |
RG Bradke |
| Subproject |
B07 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Yes |
| PMID |
42420447 |
| DOI |
10.1038/s41586-026-10755-6 |
| Publication Year |
2026 |
| Title |
An intrinsic cytoskeletal oscillator establishes neuronal polarity |
| Journal |
Nature |
| ISSN |
0028-0836 |
| eISSN |
1476-4687 |
| URL |
https://doi.org/10.1038/s41586-026-10755-6 |
| Journal Abbreviation |
Nature |
| Authors |
Lin T, Coles CH, Alfadil E, Fäßler F, Husch A, Dupraz S, Pietralla T, Narita A, Schelski M, Flynn KC, Stern S, Möhl C, Hilton BJ, Vauti F, Arnold H, Schur FKM, Bradke F |
| First Author |
Lin T |
| Last Author |
Bradke F |
External Resources
nature.c...-6.pdfhttps://www.nature.com/articles/s41586-026-10755-6.pdf Article fulltext
gro-2/178067https://publications.goettingen-research-online.de/handle/gro-2/178067 GRO.publications identifier
10090https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 NCBI taxonomy (mouse, Mus musculus)
0000-0002-6852-2900https://orcid.org/0000-0002-6852-2900 ORCID identifier (Tien-Chen Lin)
0000-0002-4160-9352https://orcid.org/0000-0002-4160-9352 ORCID identifier (Eissa Alfadil)
0000-0001-7149-769Xhttps://orcid.org/0000-0001-7149-769X ORCID identifier (Florian Fäßler)
0000-0002-1966-5227https://orcid.org/0000-0002-1966-5227 ORCID identifier (Andreas Husch)
0000-0003-4557-2611https://orcid.org/0000-0003-4557-2611 ORCID identifier (Sebastian Dupraz)
0000-0003-1504-9352https://orcid.org/0000-0003-1504-9352 ORCID identifier (Akihiro Narita)
0000-0001-8189-6686https://orcid.org/0000-0001-8189-6686 ORCID identifier (Max Schelski)
0000-0002-0829-5101https://orcid.org/0000-0002-0829-5101 ORCID identifier (Christoph Möhl)
0000-0003-2813-2294https://orcid.org/0000-0003-2813-2294 ORCID identifier (Brett J. Hilton)
0000-0003-0275-1433https://orcid.org/0000-0003-0275-1433 ORCID identifier (Franz Vauti)
0000-0002-6615-274Xhttps://orcid.org/0000-0002-6615-274X ORCID identifier (Hans-Henning Arnold)
0000-0003-4790-8078https://orcid.org/0000-0003-4790-8078 ORCID identifier (Florian K. M. Schur)
0000-0002-0345-3772https://orcid.org/0000-0002-0345-3772 ORCID identifier (Frank Bradke)
043j0f473https://ror.org/043j0f473 ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)
03gnh5541https://ror.org/03gnh5541 ROR identifier (03gnh5541, Institute of Science and Technology Austria)
04chrp450https://ror.org/04chrp450 ROR identifier (04chrp450, Nagoya University)
010nsgg66https://ror.org/010nsgg66 ROR identifier (010nsgg66, Technische Universität Braunschweig)
03rmrcq20https://ror.org/03rmrcq20 ROR identifier (03rmrcq20, University of British Columbia)
SCR_002285https://scicrunch.org/resolver/SCR_002285 SciCrunch identifier (RRID:SCR_002285, Fiji)
SCR_002630https://scicrunch.org/resolver/SCR_002630 SciCrunch identifier (RRID:SCR_002630, GitHub)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_015246https://scicrunch.org/resolver/SCR_015246 SciCrunch identifier (RRID:SCR_015246, Ilastik)
SCR_007370https://scicrunch.org/resolver/SCR_007370 SciCrunch identifier (RRID:SCR_007370, Imaris)
SCR_003297https://scicrunch.org/resolver/SCR_003297 SciCrunch identifier (RRID:SCR_003297, IMOD)
SCR_001622https://scicrunch.org/resolver/SCR_001622 SciCrunch identifier (RRID:SCR_001622, MATLAB)
SCR_016137https://scicrunch.org/resolver/SCR_016137 SciCrunch identifier (RRID:SCR_016137, Microsoft Excel)
SCR_001905https://scicrunch.org/resolver/SCR_001905 SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)
SCR_000432https://scicrunch.org/resolver/SCR_000432 SciCrunch identifier (RRID:SCR_000432, RStudio)
SCR_017293https://scicrunch.org/resolver/SCR_017293 SciCrunch identifier (RRID:SCR_017293, SerialEM)
SCR_019157https://scicrunch.org/resolver/SCR_019157 SciCrunch identifier (RRID:SCR_019157, SoftWoRx)
SCR_017377https://scicrunch.org/resolver/SCR_017377 SciCrunch identifier (RRID:SCR_017377, Zeiss LSM 700 microscope)
SCR_020925https://scicrunch.org/resolver/SCR_020925 SciCrunch identifier (RRID:SCR_020925, Zeiss LSM 880 with Airyscan Confocal Laser Scanning Microscope)
SCR_025048https://scicrunch.org/resolver/SCR_025048 SciCrunch identifier (RRID:SCR_025048, ZEISS LSM 980 with Airyscan 2 Microscope)
SCR_013672https://scicrunch.org/resolver/SCR_013672 SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10755-6/MediaObjects/41586_2026_10755_MOESM1_ESM.pdf Supplemental material
github.c...Scripthttps://github.com/darkbreaker0/IJ_NeuriteGrowthScript Supplemental material (code)
github.c...n_2026https://github.com/darkbreaker0/Arp3_neuronal_polarization_2026 Supplemental material (code)
github.c...zationhttps://github.com/DrHanLim/EzColocalization Supplemental material (code, reused)
github.com/ekatrukha/ComDet/https://github.com/ekatrukha/ComDet/ Supplemental material (code, reused)
github.com/morphonets/SNThttps://github.com/morphonets/SNT Supplemental material (code, reused)
sites.go...p/homehttps://sites.google.com/site/colocalizationcolormap/home Supplemental material (code, reused)
yapic.github.io/yapic/https://yapic.github.io/yapic/ Supplemental material (code, reused)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10755-6/MediaObjects/41586_2026_10755_MOESM4_ESM.pdf Supplemental material (peer review)
static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10755-6/MediaObjects/41586_2026_10755_MOESM2_ESM.pdf Supplemental material (reporting summary)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10755-6/MediaObjects/41586_2026_10755_MOESM6_ESM.xlsx Supplemental material (source data)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10755-6/MediaObjects/41586_2026_10755_MOESM7_ESM.xlsx Supplemental material (source data)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10755-6/MediaObjects/41586_2026_10755_MOESM8_ESM.xlsx Supplemental material (source data)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10755-6/MediaObjects/41586_2026_10755_MOESM9_ESM.xlsx Supplemental material (source data)
static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10755-6/MediaObjects/41586_2026_10755_MOESM10_ESM.xlsx Supplemental material (source data)
static-c...M.docxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10755-6/MediaObjects/41586_2026_10755_MOESM3_ESM.docx Supplemental material (table)
static-c...SM.ziphttps://static-content.springer.com/esm/art%3A10.1038%2Fs41586-026-10755-6/MediaObjects/41586_2026_10755_MOESM5_ESM.zip Supplemental material (video)
10.5281/zenodo.20118606https://doi.org/10.5281/zenodo.20118606 Zenodo identifier (10.5281/zenodo.20118606)
10.5281/zenodo.20081075https://doi.org/10.5281/zenodo.20081075 Zenodo identifier (10.5281/zenodo.20081075, reused)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0010 |
 |
primary |
GFP |
AB_300798 |
Anti-GFP antibody |
| primary-0022 |
|
primary |
TAU |
AB_3068606 |
Anti-Tau-1 Antibody, clone PC1C6 |
| primary-0023 |
|
primary |
TBB3 |
AB_262133 |
Anti-β-Tubulin III Antibody |
| primary-0024 |
|
primary |
MYH10 |
AB_11217639 |
Myosin IIb (D8H8) Rabbit Monoclonal Antibody |
| primary-0025 |
|
primary |
ARP3 |
AB_476749 |
Anti-ARP3 antibody, Mouse monoclonal |
| primary-0031 |
|
primary |
ARP3 |
|
Anti-Arp3 Antibody |
| primary-0032 |
|
primary |
ARP2 |
AB_11178936 |
ARP2 (D85D5) Rabbit Monoclonal Antibody |
| primary-0033 |
|
primary |
ARPC1A |
AB_1078215 |
Anti-ARPC1A antibody produced in rabbit |
| primary-0034 |
|
primary |
ARPC3 |
AB_399557 |
Purified Mouse Anti- p21-Arc |
| primary-0035 |
|
primary |
ARPC4 |
AB_2059954 |
p20-ARC (FL-168) |
| primary-0036 |
|
primary |
ARPC5 |
AB_2060065 |
p16-ARC Antikörper (C-3) |
| primary-0037 |
|
primary |
MYL9 |
AB_2250969 |
Phospho-Myosin Light Chain 2 (Ser19) Mouse mAb |
| primary-0038 |
|
primary |
MYL12A |
AB_303094 |
Anti-MYL12A (phospho S19) antibody |
| primary-0039 |
|
primary |
MYL9 |
AB_10985405 |
MYL9 Polyclonal Antibody |
| primary-0040 |
|
primary |
MYL9 |
AB_10692513 |
Myosin Light Chain 2 Antibody |
| primary-0041 |
|
primary |
GAPDH |
AB_1616730 |
Monoclonal Antibody to GAPDH (Loading Control) - Purified |
| secondary-0026 |
|
secondary |
|
AB_221605 |
Goat Anti-Rabbit IgG (H+L) Alexa Fluor 405 |
| secondary-0027 |
|
secondary |
|
AB_2535844 |
Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 |
| secondary-0028 |
|
secondary |
|
AB_2576217 |
Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
| secondary-0029 |
|
secondary |
|
AB_141637 |
Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 594 |
| secondary-0030 |
|
secondary |
|
AB_2534091 |
Goat anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 594 |
| secondary-0042 |
|
secondary |
|
AB_3095590 |
StrepMAB-Classic HRP |
| secondary-0043 |
|
secondary |
|
AB_228302 |
Goat anti-Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, HRP |
| secondary-0044 |
|
secondary |
|
AB_228213 |
Donkey anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, HRP |