| Property |
Value |
| Working Groups |
RG Vona |
| Subproject |
A03 |
| Open Access |
Yes |
| Publication Type |
Preprint |
| Peer Reviewed |
No |
| DOI |
10.64898/2026.03.27.26349271 |
| Publication Year |
2026 |
| Title |
FRMPD4, a causal gene for intellectual disability and epilepsy, is associated with X-linked non-syndromic hearing loss |
| Journal |
medRxiv |
| eISSN |
3067-2007 |
| URL |
https://doi.org/10.64898/2026.03.27.26349271 |
| Journal Abbreviation |
medRxiv |
| Extra |
Not yet finally published in a peer-reviewed journal |
| Authors |
Liedtke D, Rak K, Schrode KM, Hehlert P, Chamanrou N, Bengl D, Katana R, Heydaran S, Doll J, Han M, Nanda I, Senthilan PR, Jürgens L, Bieniussa L, Voelker J, Neuner C, Hofrichter MA, Schröder J, Schellens RT, de Vrieze E, van Wijk E, Zechner U, Herms S, Hoffmann P, Müller T, Dittrich M, Bartsch O, Krawitz PM, Klopocki E, Shehata-Dieler W, Maroofian R, Wang T, Worley PF, Göpfert MC, Galehdari H, Lauer AM, Haaf T, Vona B |
| First Author |
Liedtke D |
| Last Author |
Vona B |
External Resources
138400https://www.addgene.org/138400 Addgene identifier (138400, reused)
138401https://www.addgene.org/138401 Addgene identifier (138401, reused)
51434https://www.addgene.org/51434 Addgene identifier (51434, reused)
medrxiv....ll.pdfhttps://www.medrxiv.org/content/10.64898/2026.03.27.26349271v1.full.pdf Article fulltext
2/165198https://publications.goettingen-research-online.de/handle/2/165198 GRO.publications identifier
9758https://www.ncbi.nlm.nih.gov/gene/9758 NCBI gene (9758)
7227https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=7227 NCBI taxonomy (fruit fly, Drosophila melanogaster)
9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)
10090https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 NCBI taxonomy (mouse, Mus musculus)
7955https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id= 7955 NCBI taxonomy (zebrafish, Danio rerio)
300838https://www.omim.org/entry/300838 OMIM identifier (300838, FERM AND PDZ DOMAINS-CONTAINING PROTEIN 4; FRMPD4)
0000-0003-0934-7169https://orcid.org/0000-0003-0934-7169 ORCID identifier (Daniel Liedtke)
0000-0003-2109-3536https://orcid.org/0000-0003-2109-3536 ORCID identifier (Kristen Rak)
0000-0003-3794-3267https://orcid.org/0000-0003-3794-3267 ORCID identifier (Philip Hehlert)
0009-0009-6221-8359https://orcid.org/0009-0009-6221-8359 ORCID identifier (Niloofar Chamanrou)
0000-0002-0037-9079https://orcid.org/0000-0002-0037-9079 ORCID identifier (Julia Doll)
0000-0003-3921-8886https://orcid.org/0000-0003-3921-8886 ORCID identifier (Pingkalai Rajeswaran Senthilan)
0000-0001-8024-6681https://orcid.org/0000-0001-8024-6681 ORCID identifier (Linda Bieniussa)
0009-0006-1076-4401https://orcid.org/0009-0006-1076-4401 ORCID identifier (Jörg Schröder)
0000-0002-3575-1301https://orcid.org/0000-0002-3575-1301 ORCID identifier (Renske Schellens)
0000-0003-3448-3269https://orcid.org/0000-0003-3448-3269 ORCID identifier (Erik de Vrieze)
0000-0002-5702-3460https://orcid.org/0000-0002-5702-3460 ORCID identifier (Erwin van Wijk)
0000-0002-2786-8200https://orcid.org/0000-0002-2786-8200 ORCID identifier (Stefan Herms)
0000-0002-6573-983Xhttps://orcid.org/0000-0002-6573-983X ORCID identifier (Per Hoffmann)
0000-0001-6329-696Xhttps://orcid.org/0000-0001-6329-696X ORCID identifier (Oliver Bartsch)
0000-0002-3194-8625https://orcid.org/0000-0002-3194-8625 ORCID identifier (Peter M. Krawitz)
0000-0003-1438-2081https://orcid.org/0000-0003-1438-2081 ORCID identifier (Eva Klopocki)
0009-0000-9264-8565https://orcid.org/0009-0000-9264-8565 ORCID identifier (Wafaa Shehata-Dieler)
0000-0001-6763-1542https://orcid.org/0000-0001-6763-1542 ORCID identifier (Reza Maroofian)
0000-0002-5086-614Xhttps://orcid.org/0000-0002-5086-614X ORCID identifier (Paul Worley)
0000-0001-8201-5334https://orcid.org/0000-0001-8201-5334 ORCID identifier (Martin C. Göpfert)
0000-0001-6281-4809https://orcid.org/0000-0001-6281-4809 ORCID identifier (Hamid Galehdari)
0000-0003-4184-7374https://orcid.org/0000-0003-4184-7374 ORCID identifier (Amanda Lauer)
0000-0002-0737-0763https://orcid.org/0000-0002-0737-0763 ORCID identifier (Thomas Haaf)
0000-0002-6719-3447https://orcid.org/0000-0002-6719-3447 ORCID identifier (Barbara Christine Vona)
1393https://prod.mbexc.uni-goettingen.de/literature/publications/1393 Published Data Registry entry (MBExC)
1/753https://mbexc.uni-goettingen.de/archive/1/753 Research Data Archive MBExC (supplemental material)
04b6nzv94https://ror.org/04b6nzv94 ROR identifier (04b6nzv94, Brigham and Women's Hospital)
05a0ya142https://ror.org/05a0ya142 ROR identifier (05a0ya142, Broad Institute)
02nv7yv05https://ror.org/02nv7yv05 ROR identifier (02nv7yv05, Forschungszentrum Jülich)
02f99v835https://ror.org/02f99v835 ROR identifier (02f99v835, German Primate Center)
023b0x485https://ror.org/023b0x485 ROR identifier (023b0x485, Johannes Gutenberg University Mainz)
00za53h95https://ror.org/00za53h95 ROR identifier (00za53h95, Johns Hopkins University)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
05wg1m734https://ror.org/05wg1m734 ROR identifier (05wg1m734, Radboud University Nijmegen Medical Centre)
01k3mbs15https://ror.org/01k3mbs15 ROR identifier (01k3mbs15, Shahid Chamran University of Ahvaz)
03pvr2g57https://ror.org/03pvr2g57 ROR identifier (03pvr2g57, Universitätsklinikum Würzburg)
02jx3x895https://ror.org/02jx3x895 ROR identifier (02jx3x895, University College London)
04k51q396https://ror.org/04k51q396 ROR identifier (04k51q396, University Hospital of Basel)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
00fbnyb24https://ror.org/00fbnyb24 ROR identifier (00fbnyb24, University of Würzburg)
041nas322https://ror.org/041nas322 ROR identifier (041nas322, University of Bonn)
01y9bpm73https://ror.org/01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)
02s6k3f65https://ror.org/02s6k3f65 ROR identifier (02s6k3f65, University of Basel)
SCR_010279https://scicrunch.org/resolver/SCR_010279 SciCrunch identifier (RRID:SCR_010279, Adobe Illustrator)
SCR_018393https://scicrunch.org/resolver/SCR_018393 SciCrunch identifier (RRID:SCR_018393, Combined Annotation Dependent Depletion)
SCR_023641https://scicrunch.org/resolver/SCR_023641 SciCrunch identifier (RRID:SCR_023641, CRISPR Target Finder)
SCR_005231https://scicrunch.org/resolver/SCR_005231 SciCrunch identifier (RRID:SCR_005231, GeneTalk)
SCR_014964https://scicrunch.org/resolver/SCR_014964 SciCrunch identifier (RRID:SCR_014964, Genome Aggregation Database)
SCR_017632https://scicrunch.org/resolver/SCR_017632 SciCrunch identifier (RRID:SCR_017632, iBright Analysis Software)
SCR_020130https://scicrunch.org/resolver/SCR_020130 SciCrunch identifier (RRID:SCR_020130, Illumina HiSeq2000 Sequencing System)
SCR_016386https://scicrunch.org/resolver/SCR_016386 SciCrunch identifier (RRID:SCR_016386, Illumina HiSeq 3000/HiSeq 4000 System)
SCR_003070https://scicrunch.org/resolver/SCR_003070 SciCrunch identifier (RRID:SCR_003070, ImageJ)
SCR_013673https://scicrunch.org/resolver/SCR_013673 SciCrunch identifier (RRID:SCR_013673, Leica Application Suite X)
SCR_016707https://scicrunch.org/resolver/SCR_016707 SciCrunch identifier (RRID:SCR_016707, MaxEntScan)
SCR_010777https://scicrunch.org/resolver/SCR_010777 SciCrunch identifier (RRID:SCR_010777, MutationTaster)
SCR_013189https://scicrunch.org/resolver/SCR_013189 SciCrunch identifier (RRID:SCR_013189, PolyPhen)
SCR_001905https://scicrunch.org/resolver/SCR_001905 SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)
SCR_013850https://scicrunch.org/resolver/SCR_013850 SciCrunch identifier (RRID:SCR_013850, Residual Variation Intolerance Score (RVIS))
SCR_012813https://scicrunch.org/resolver/SCR_012813 SciCrunch identifier (RRID:SCR_012813, SIFT)
medrxiv....d=truehttps://www.medrxiv.org/content/medrxiv/early/2026/03/30/2026.03.27.26349271/DC1/embed/media-1.zip?download=true Supplemental material (video)
medrxiv....d=truehttps://www.medrxiv.org/content/medrxiv/early/2026/03/30/2026.03.27.26349271/DC2/embed/media-2.zip?download=true Supplemental material (video)
10.5281/zenodo.18507823https://doi.org/10.5281/zenodo.18507823 Zenodo identifier (10.5281/zenodo.18507823)