| Property |
Value |
| Working Groups |
RG Beutner, 
RG Moser, 
RG Strenzke, 
RG Vona |
| Subproject |
A01, A03, A04, B01, B11 |
| Open Access |
Yes |
| Publication Type |
Journal Article |
| Peer Reviewed |
Unknown |
| PMID |
41091875 |
| DOI |
10.1126/sciadv.ady8532 |
| Publication Year |
2025 |
| Title |
Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing |
| Journal |
Science Advances |
| ISSN |
2375-2548 |
| eISSN |
2375-2548 |
| URL |
https://doi.org/10.1126/sciadv.ady8532 |
| Issue |
42 |
| Volume |
11 |
| Journal Abbreviation |
Sci Adv |
| Authors |
Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Szabo CZK, Pena V, Pape C, Grubmüller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T |
| First Author |
Chen H |
| Last Author |
Moser T |
External Resources
science....d=truehttps://www.science.org/doi/pdf/10.1126/sciadv.ady8532?download=true Article fulltext
EMD-53046https://www.ebi.ac.uk/pdbe/emdb/EMD-53046 EMBL-EBI EMDB identifier (EMD-53046)
EMD-54802https://www.ebi.ac.uk/pdbe/emdb/EMD-54802 EMBL-EBI EMDB identifier (EMD-54802)
EMD-54805https://www.ebi.ac.uk/pdbe/emdb/EMD-54805 EMBL-EBI EMDB identifier (EMD-54805)
EMD-54809https://www.ebi.ac.uk/pdbe/emdb/EMD-54809 EMBL-EBI EMDB identifier (EMD-54809)
EMD-54827https://www.ebi.ac.uk/pdbe/emdb/EMD-54827 EMBL-EBI EMDB identifier (EMD-54827)
EMD-54883https://www.ebi.ac.uk/pdbe/emdb/EMD-54883 EMBL-EBI EMDB identifier (EMD-54883)
EMD-54923https://www.ebi.ac.uk/pdbe/emdb/EMD-54923 EMBL-EBI EMDB identifier (EMD-54923)
10090https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 NCBI taxonomy (mouse, Mus musculus)
0009-0003-1357-5161https://orcid.org/0009-0003-1357-5161 ORCID identifier (Han Chen)
0000-0002-6466-176Xhttps://orcid.org/0000-0002-6466-176X ORCID identifier (Constantin Cretu)
0009-0003-1639-9298https://orcid.org/0009-0003-1639-9298 ORCID identifier (Abigail Trebilcock)
0009-0009-5116-8931https://orcid.org/0009-0009-5116-8931 ORCID identifier (Natalia Evdokimova)
0009-0006-3846-9447https://orcid.org/0009-0006-3846-9447 ORCID identifier (Fritz Benseler)
0009-0005-6776-4130https://orcid.org/0009-0005-6776-4130 ORCID identifier (Sophia Mutschall)
0000-0002-0729-4713https://orcid.org/0000-0002-0729-4713 ORCID identifier (Klara Friederike Esch)
0000-0002-7013-5504https://orcid.org/0000-0002-7013-5504 ORCID identifier (Vladimir Pena)
0000-0001-6562-7187https://orcid.org/0000-0001-6562-7187 ORCID identifier (Constantin Pape)
0000-0002-3270-3144https://orcid.org/0000-0002-3270-3144 ORCID identifier (Helmut Grubmüller)
0000-0003-1673-1046https://orcid.org/0000-0003-1673-1046 ORCID identifier (Nicola Strenzke)
0000-0003-0938-8534https://orcid.org/0000-0003-0938-8534 ORCID identifier (Nils Brose)
0000-0001-8868-8716https://orcid.org/0000-0001-8868-8716 ORCID identifier (Carolin Wichmann)
0000-0002-1825-0433https://orcid.org/0000-0002-1825-0433 ORCID identifier (Julia Preobraschenski)
0000-0001-7145-0533https://orcid.org/0000-0001-7145-0533 ORCID identifier (Tobias Moser)
403https://sfb1286.uni-goettingen.de/literature/publications/403 Published Data Registry entry (CRC 1286)
14https://rdp.sfb1690.uni-goettingen.de/literature/publication/14 Published Data Registry entry (CRC 1690, preprint)
1279https://prod.mbexc.uni-goettingen.de/literature/publications/1279 Published Data Registry entry (MBExC)
9QE2https://www.rcsb.org/structure/9QE2 RCSB PDB Identifier (DOI:10.2210/pdb9QE2/pdb)
9SE5https://www.rcsb.org/structure/9SE5 RCSB PDB Identifier (DOI:10.2210/pdb9SE5/pdb)
9SEAhttps://www.rcsb.org/structure/9SEA RCSB PDB Identifier (DOI:10.2210/pdb9SEA/pdb)
9SEGhttps://www.rcsb.org/structure/9SEG RCSB PDB Identifier (DOI:10.2210/pdb9SEG/pdb)
9SFLhttps://www.rcsb.org/structure/9SFL RCSB PDB Identifier (DOI:10.2210/pdb9SFL/pdb)
9SH0https://www.rcsb.org/structure/9SH0 RCSB PDB Identifier (DOI:10.2210/pdb9SH0/pdb)
9SI1https://www.rcsb.org/structure/9SI1 RCSB PDB Identifier (DOI:10.2210/pdb9SI1/pdb)
05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)
03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)
021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)
043jzw605https://ror.org/043jzw605 ROR identifier (043jzw605, Institute of Cancer Research)
SCR_025454https://scicrunch.org/resolver/SCR_025454 SciCrunch identifier (RRID:SCR_025454, AlphaFold)
SCR_014222https://scicrunch.org/resolver/SCR_014222 SciCrunch identifier (RRID:SCR_014222, Coot)
SCR_016501https://scicrunch.org/resolver/SCR_016501 SciCrunch identifier (RRID:SCR_016501, cryoSPARC)
SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)
SCR_014565https://scicrunch.org/resolver/SCR_014565 SciCrunch identifier (RRID:SCR_014565, GROMACS)
SCR_000325https://scicrunch.org/resolver/SCR_000325 SciCrunch identifier (RRID:SCR_000325, IGOR Pro)
SCR_003070https://scicrunch.org/resolver/SCR_003070 SciCrunch identifier (RRID:SCR_003070, ImageJ)
SCR_003297https://scicrunch.org/resolver/SCR_003297 SciCrunch identifier (RRID:SCR_003297, IMOD)
SCR_025577https://scicrunch.org/resolver/SCR_025577 SciCrunch identifier (RRID:SCR_025577, ISOLDE)
SCR_001622https://scicrunch.org/resolver/SCR_001622 SciCrunch identifier (RRID:SCR_001622, MATLAB)
SCR_025610https://scicrunch.org/resolver/SCR_025610 SciCrunch identifier (RRID:SCR_025610, MDAnalysis)
SCR_014224https://scicrunch.org/resolver/SCR_014224 SciCrunch identifier (RRID:SCR_014224, Phenix)
SCR_015749https://scicrunch.org/resolver/SCR_015749 SciCrunch identifier (RRID:SCR_015749, PISA)
SCR_008394https://scicrunch.org/resolver/SCR_008394 SciCrunch identifier (RRID:SCR_008394, Python)
SCR_016274https://scicrunch.org/resolver/SCR_016274 SciCrunch identifier (RRID:SCR_016274, RELION)
SCR_017293https://scicrunch.org/resolver/SCR_017293 SciCrunch identifier (RRID:SCR_017293, SerialEM)
SCR_015872https://scicrunch.org/resolver/SCR_015872 SciCrunch identifier (RRID:SCR_015872, UCSF ChimeraX)
science....sm.pdfhttps://www.science.org/doi/suppl/10.1126/sciadv.ady8532/suppl_file/sciadv.ady8532_sm.pdf Supplemental material
science....s4.ziphttps://www.science.org/doi/suppl/10.1126/sciadv.ady8532/suppl_file/sciadv.ady8532_movies_s1_to_s4.zip Supplemental material (video)
Linked Antibodies
| PID |
AG |
Type |
Antigen symbol |
Antibody Registry ID |
Name |
| primary-0001 |
|
primary |
OTOF |
AB_881807 |
Anti-Otoferlin antibody |
| primary-0002 |
|
primary |
PRVA |
AB_2619887 |
Parvalbumin antibody |
| primary-0003 |
|
primary |
SLC17A8 |
AB_887886 |
Anti-VGLUT 3 antibody |
| primary-0004 |
|
primary |
CtBP2 |
AB_399431 |
Purified Mouse Anti-CtBP2 |
| secondary-0005 |
|
secondary |
|
AB_2620153 |
goat anti-mouse STAR 580 |
| secondary-0006 |
|
secondary |
|
AB_2534096 |
Goat anti-Chicken IgY (H+L) Secondary Antibody, Alexa Fluor 488 |
| secondary-0007 |
|
secondary |
|
AB_2535812 |
Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 647 |
| secondary-0008 |
|
secondary |
|
AB_143165 |
Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 |
Linked Mouselines